My oldest daughter is 22.. I am very much depress as she have one boy friend.. Shall I talk with her regarding their relationship?

Yes, having 1 boyfriend at 22 is a sign of certain mental disease. By her age she should be dating at LEAST 5 men and three women. Mind you these are her "dates". She shouldn't have sex with them. She should have a seperate collection of priests and spiritual advisors who actually perform the sex on your daughter so that demons or ghosts of the long dead cannot enter her vagina and turn her into a lesbian.

So sad.. I think you have to talk with your daughter..