The questions that thinking people need to ask when they hear a story like this are:

1. What are the other factors that might have caused Joe's symptoms?
2. What standards were used to judge Joe's apparent "deficiency" and are they reflective of what is optimal for the human body? How do we know this?
3. Are the nutrients from the supplements in Joe's bloodstream doing what they're supposed to be doing, or are they there being ushered out as waste?
4. Is the fact that Joe's symptoms went away after supplement therapy proof that there was a deficiency? If not, what other factors might have caused the cessation of Joe's symptoms?